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EPSRC Support by Research Area (Chemical Biology and Biological Chemistry) in Theme (Physical Sciences)

Research areas are used to describe EPSRC's portfolio of excellent long term research and high quality postgraduate training.

Grants are classified using one or more research areas. The number and value of grants listed below reflects how the theme portfolio is described by this research area.

Please note: some research areas will appear under multiple themes. There is no unique, absolute, relationship between a research area and a theme.

Grant TitlePrincipal
Investigator		OrganisationDepartmentTotal Grant
Value (£)
A Chemical Toolkit to Define Formaldehyde’s Enigmatic BiologyHopkinson, Dr RJUniversity of LeicesterChemistry 397,133
A Platform for Chemical Probe Identification and Optimization Facilitating Interrogation of Biological MechanismsWilson, Professor AJUniversity of LeedsSch of Chemistry 1,147,345
A programmable, cell-agnostic DNA nano-technology platform for CRISPR gene editingDi Michele, Dr LImperial College LondonChemistry 201,597
A Protein Functionalization Platform Based on Selective Modification at Methionine ResiduesGaunt, Professor MUniversity of CambridgeChemistry 1,892,760
A regionally strategic NMR spectrometer with globally unique high pressure and reaction monitoring capabilityAdams, Dr RWUniversity of Manchester, TheChemistry 1,698,226
Aberration-Corrected Scanning Transmission Electron Microscope with atomic resolution spectroscopy under controlled environmental conditions: AC-eSTEMLazarov, Professor VUniversity of YorkPhysics 3,250,534
An Artificial RibosomeO'Reilly, Professor RKUniversity of BirminghamSchool of Chemistry 581,943
An Artificial RibosomeTurberfield, Professor AJUniversity of OxfordOxford Physics 664,201
An EPSRC National Research Facility to facilitate Data Science in the Physical Sciences: The Physical Sciences Data science Service (PSDS)Coles, Professor SJUniversity of SouthamptonSch of Chemistry 2,996,067
Anti tumour agents from natural products - new approaches to targeting ultra potent analogues of the duocarmycinsSearcey, Professor MUniversity of East AngliaPharmacy 450,207
Autonomous Discovery of Functional Small MoleculesNelson, Professor ASUniversity of LeedsSch of Chemistry 1,245,808
Bioorthogonal Gold Chemistry to Explore Novel Biomedical ApplicationsUnciti-Broceta, Professor AUniversity of EdinburghEdinburgh Cancer Research Centre 513,211
Chemical biology tools for investigating the chemistry of cellular REDOX stressConway, Professor SJUniversity of OxfordOxford Chemistry 5,334,387
Chemical probes to decode the subcellular redox-regulated proteomeWright, Dr MHUniversity of LeedsSch of Chemistry 277,691
Chemical Tools for Probing Histone Deacetylase Multiprotein Complexes in DiseaseHodgkinson, Dr JTUniversity of LeicesterChemistry 246,269
Controlling cell-free expression with temperature-sensitive polymer-DNA conjugatesBooth, Dr MJUniversity of OxfordOxford Chemistry 284,195
Controlling membrane translocation for artificial signal transductionWilliams, Professor NHUniversity of SheffieldChemistry 356,411
CRISPR ChemistryBrown, Professor TUniversity of OxfordOxford Chemistry 254,184
C-Terminal Selective Ligation to Access Homogeneous Antibody ConjugatesBaker, Dr JRUCLChemistry 444,295
Directed Molecular Recognition through Next-Generation Hybrid Molecular ImprintingTurner, Dr NWDe Montfort UniversitySchool of Pharmacy 269,828
Directed Molecular Recognition through Next-Generation Hybrid Molecular ImprintingFulton, Dr DANewcastle UniversitySch of Natural & Environmental Sciences 308,037
Dynamic physicochemical nanoscale imaging at the solid-liquid interfaceGeorge, Professor MUniversity of NottinghamSch of Chemistry 1,171,682
Efficient modelling and validation of cryptic protein binding sites for drug discoveryMichel, Dr JUniversity of EdinburghSch of Chemistry 198,251
EPSRC-SFI: Glycoconjugate tools for sensing endoglycosidase activity: a diagnostic sugar probe for heparanaseMiller, Dr GJKeele UniversityFaculty of Natural Sciences 368,582
Expanding the biochemical toolbox for protein modification at cysteineMacMillan, Dr DUCLChemistry 375,298
Exploiting Membrane Lipidation for Advanced Drug DeliverySanderson, Dr JMDurham, University ofChemistry 201,184
Exploration of Linking Chemistry in the Design of Aptamer-Molecularly Imprinted Polymer Hybrids (aptaMIPs)Turner, Dr NWDe Montfort UniversitySchool of Pharmacy 296,003
High Resolution High Throughput Mass Spectrometry to Characterise Materials, Chemicals, and BioCatalystsBarran, Professor PEUniversity of Manchester, TheChemistry 1,099,473
High-sensitivity multinuclear 600 MHz NMR for synthesis, catalysis and functional materialsClaridge, Professor TUniversity of OxfordOxford Chemistry 971,862
Hydrophobic Gating in Membrane Nanopores: Water at the NanoscaleSansom, Professor MUniversity of OxfordBiochemistry 379,691
Hyperfine Resolution and Advanced Structural Analysis to Enable Next-Generation Molecular ScienceO'Connor, Professor PBUniversity of WarwickChemistry 3,101,722
Immuno-chemotherapeutic Metal Complexes for Cancer Stem Cell-Directed TherapySuntharalingam, Dr KUniversity of LeicesterChemistry 217,731
Integrated computational and synthetic tools to drive the discovery of orthosteric protein-protein interaction inhibitorsWilson, Professor AJUniversity of LeedsSch of Chemistry 2,751,527
Interrogating the Nisin:lipid II Interaction: A Chemical Biology ApproachCochrane, Dr SQueen's University of BelfastSch of Chemistry and Chemical Eng 243,690
Interrogating the nisin:lipid II interaction: a chemical biology approachTabor, Professor AUCLChemistry 759,213
Ion Beam Analysis for the 2020's and Beyond: An Integration of Elemental Mapping and 'omics'Bailey, Dr MJUniversity of SurreyChemistry 1,025,483
Light-NMR spectroscopy: tools and applicationsGolovanov, Dr APUniversity of Manchester, TheChemistry 202,164
Luminescent Host Molecules for Multisite Recognition of Polyphosphate AnionsButler, Dr SJLoughborough UniversityChemistry 247,277
Meta-Smart: Merging de novo designed biomolecules with plasmonic metamaterials for new technologiesKadodwala, Professor MUniversity of GlasgowSchool of Chemistry 1,022,161
Modify-catch-release-repeat: Reversible bioconjugations for controlled release of small molecules from antibodies and their fragmentsFascione, Dr M AUniversity of YorkChemistry 397,840
NAMS: Native ambient mass spectrometryCooper, Professor HJUniversity of BirminghamSch of Biosciences 1,241,472
Nanostar Sieving for Oligonucleotides Manufacture (NanoSieveOligo)Livingston, Professor AImperial College LondonChemical Engineering 562,145
New Directions in Bioisostere ResearchAnderson, Professor EAUniversity of OxfordOxford Chemistry 572,768
New Reagents for Protein ModificationBaud, Dr MUniversity of SouthamptonSch of Chemistry 195,281
Next generation molecular imaging and therapy with radionuclidesBlower, Professor PKings College LondonImaging & Biomedical Engineering 6,437,106
Partially fluorinated alkyl motifs for pharmaceuticals and agrochemicals researchO'Hagan, Professor DUniversity of St AndrewsChemistry 424,425
PEPR - A centre for Pulse Electron Paramagnetic Resonance spectroscopy at Imperial CollegeRoessler, Dr MMImperial College LondonChemistry 2,288,049
Properties and applications of Janus faced fluorocyclohexanesO'Hagan, Professor DUniversity of St AndrewsChemistry 482,983
Property-Enhanced PorphyrinsChauvet, Dr A A PUniversity of SheffieldChemistry 379,306
Resurrecting ancestral sugars: a molecular archaeology approach to immunotherapyFascione, Dr M AUniversity of YorkChemistry 201,973
Shining Light on Metalloprotein Mechanism: Single Protein Crystal Catalytic Studies Driven by 'Caged' Electron SourcesAsh, Dr PAUniversity of LeicesterChemistry 186,373
Simulating catalysis: Multiscale embedding of machine learning potentialsvan der Kamp, Dr MWUniversity of BristolBiochemistry 391,585
Singlet Fission in Carotenoid Aggregates (SIFICA)Clark, Dr JUniversity of SheffieldPhysics and Astronomy 851,312
Singlet Fission in Carotenoid Aggregates (SIFICA)Barford, Professor WUniversity of OxfordOxford Chemistry 294,636
Site-selective antibody modification by cysteine-to-lysine transfer (CLT)Baker, Dr JRUCLChemistry 411,777
Site-selective functionalisation of peptides and proteins via free-radical-induced dechalcogenationMitchell, Dr NJUniversity of NottinghamSch of Chemistry 428,349
Smart hydrophilic/ hydrophobic switches for targeted membrane deliveryHaynes, Dr C J EUCLChemistry 391,336
Software for experimentally driven macromolecular modellingDegiacomi, Dr MDurham, University ofChemistry 687,453
Solving the sampling problem in molecular simulations by Sequential Monte CarloEssex, Professor JWUniversity of SouthamptonSch of Chemistry 201,568
Structural dynamics and photoinduced electron transferVlcek, Professor AQueen Mary University of LondonSch of Biological and Chemical Sciences 649,756
Structural Dynamics in LOV Domain Photosensor ProteinsMeech, Professor SUniversity of East AngliaChemistry 352,953
Structure, mechanism and assembly of a nano-scale biological rotary electric motorBerry, Professor RMUniversity of OxfordOxford Physics 2,042,298
Supramolecular Designs on Dynamic Covalent Protein RecognitionThompson, Dr SUniversity of SouthamptonSch of Chemistry 244,859
Switching On and Powering Molecular Machines: Ultrafast Dynamics of PhotoswitchesMeech, Professor SUniversity of East AngliaChemistry 362,388
Synthesis of novel brevicidine and laterocidine analogues active against multi-drug-resistant Gram-negative bacteriaCochrane, Dr SQueen's University of BelfastSch of Chemistry and Chemical Eng 391,380
The UK High-Field Solid-State NMR National Research FacilityWilliamson, Dr PTFUniversity of SouthamptonSch of Biological Sciences 51,797
The UK High-Field Solid-State NMR National Research FacilityAshbrook, Professor SEMUniversity of St AndrewsChemistry 30,069
The UK High-Field Solid-State NMR National Research FacilityTitman, Dr JUniversity of NottinghamSch of Chemistry 43,315
The UK High-Field Solid-State NMR National Research FacilityBlanc, Dr FUniversity of LiverpoolChemistry 23,982
The UK High-Field Solid-State NMR National Research FacilityBrown, Professor SPUniversity of WarwickPhysics 2,431,378
The UK High-Field Solid-State NMR National Research FacilityGriffin, Dr JLancaster UniversityChemistry 22,420
Unravelling Design Rules For Creating Water Purification Membranes Based On Immobilized Aquaporin ProteinsYazaydin, Dr OUCLChemical Engineering 201,905
VIRTACs - Protein Degradation as an Anti-Viral StrategyFrance, Dr D JUniversity of GlasgowSchool of Chemistry 402,635

Total Number of Grants: 73
Total Value of Grants: £61,726,192

The grant value may include the cost of access to facilities (these funds are not awarded to the grant holding organisation).