| EPSRC Reference: |
EP/C014553/1 |
| Title: |
Rotational optic lattice modes in NIS spectroscopy of molecules containing off centre iron atoms. |
| Principal Investigator: |
Jayasooriya, Dr UA |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
University of East Anglia |
| Scheme: |
Overseas Travel Grants Pre-FEC |
| Starts: |
11 January 2006 |
Ends: |
10 July 2006 |
Value (£): |
4,575
|
| EPSRC Research Topic Classifications: |
| Chemical Biology |
Chemical Synthetic Methodology |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Iron atoms are at the centers of a large number of biological molecules such as proteins and enzymes, and are crucially important to their function. However the concentrations of these atoms compared to the bulk is very small indeed. Therefore it is necessary to develop novel methods to determine the structure and function of these active sites. Measurement and understanding the vibrations of an atom often provides clues to structure and function not gleaned by other methods. Nuclear Inelastic Scattering (NIS) is an emerging technique that has the potential to selectively provide such information on iron atoms in the presence of all the other atoms. After some initial studies of iron-sulfur cluster protein models, we postulated the possibility of observing the whole body rotations of these groups using NIS spectroscopy when the clusters involved have off centre iron atoms. The present experiment is to prove this hypothesis by studying the NIS spectra of a molecule with a linear arrangement of three iron atoms, where we can select the iron atoms we want to observe by selective isotopic substitutions with the 57Fe isotopes. We therefore expect the whole body rotations of this molecule to be abserved only when the off centre iron atoms are substituted.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.uea.ac.uk |