| EPSRC Reference: |
EP/C512049/1 |
| Title: |
The Direct Heck Reaction On Porphyrins As A Novel Method For Introduction Of Beta-Substituents and Pi-Extension To Give New Chromophores |
| Principal Investigator: |
Cammidge, Professor AN |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of East Anglia |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2005 |
Ends: |
30 September 2007 |
Value (£): |
149,898
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Towards the end of another project (funded by The Leverhulme Trust) we made the remarkable discovery that intramolecular palladium catalysed (Heck) coupling could be achieved directly onto the porphyrin beta-positions. It is well known that, in any resonance form of porphyrins, two double bonds do not contribute to the overall aromatic system. Reduction (which preserves this aromaticity) to give chlorins is well known but no one has ever considered using these beta-positions as substrates for Heck coupling. The chemistry has enormous potential along both synthesis and materials paths. The intramolecular reactions lead to new, pi-extended planar porphyrins which will show favourable optical properties (red-shifted absorption). The intermolecular reaction offers a new and versatile method for introduction of beta-substituents. Use of blocking groups in the meso-positions could allow control over this substitution.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.uea.ac.uk |