Details of Grant 

EPSRC Reference:	EP/C51808X/1
Title:	Studies on the Addition of radicals to Furans
Principal Investigator:	Parsons, Professor P
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Sussex
Scheme:	Standard Research (Pre-FEC)
Starts:	30 September 2005	Ends:	29 September 2008	Value (£):	277,082
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals Healthcare Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
Naturtally occurring chemicals often possess potent biological activity of interest to the Pharmaceutical Industry and the medical profession. Many of these substances have complex structures and thus new and highly efficient methods need to be developed in order to prepare these important materials. This proposal is concerned with the development of new and general methods for the construction of highly substituted aromatic rings which are often very difficult to make, and appear in many biologically important drugs and natural substance. The new methods involving radical and palladium chemistry will feature a 'one pot' reaction sequence in which many transformations take place. These 'zip' reaction sequences will provide the core of a number of important drug substances in an efficient and environmentally friendly manner. These novel methods will be used to make materials such as lactonamycin which is a highly important antibiotic active against MRSA which has become a major cause of illness and death in hospitals. Last year alone more than 5,000 patients died as a result of MRSA (superbug) infection after surgery. Although hospital cleanliness is of paramount importance in the control of hospital infections new antibiotics are desperately needed in order to control superbug infections post surgery. The work in this proposal seeks to develop new antibiotics active against MRSA. The development of new routes to the steroids will allow flexible access to a range of potential drug substances.Many steroids possess potent biological activity including immunosuppressant,antiinflammatory and anticancer activity and this work will provide a range of steroidal structures for biological evaluation.
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Organisation Website:	http://www.sussex.ac.uk