| EPSRC Reference: |
EP/C523067/1 |
| Title: |
Asymmetric Oxidation using Immobilised Catalysts |
| Principal Investigator: |
Hutchings, Professor G |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2006 |
Ends: |
30 November 2008 |
Value (£): |
268,115
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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We have recently discovered a new catalytic procedure for asymmetric epoxidation, applicable to unfunctionalized alkene substrates in solution. We would emphasise the extreme simplicity of the procedure described, the ease of preparation of a wide range of catalysts without need for chromatography, the absence of any sensitive materials or toxic heavy metals, the use of water as co-solvent, and the retention of double bond stereochemistry. The procedure requires no close monitoring, and provides remarkably clean reactions in an inexpensive, simple, and rapid process using minimal quantities of catalyst. Overall, the synthesis of a typical catalyst and the asymmetric oxidation together takes no longer than 6 hours. Further development by modification of catalyst structure and extension to functionalized alkene substrates is now desirable. This proposal alms to improve an these initial findings and we seek to prepare improved activity catalysts and to improve the scope aid generally of the approach. We plan to develop immobilised catalysts in which the catalysts are retained on the surface of inorganic supports by electrostatic Interaction. We plan to develop a new stable, fully reusable catalyst for important oxidation reactions.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |