| EPSRC Reference: |
EP/C549309/1 |
| Title: |
The Structural Characterisation of Melt-Derived Bioactive Glasses |
| Principal Investigator: |
Law, Professor R |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 August 2005 |
Ends: |
30 November 2008 |
Value (£): |
279,858
|
| EPSRC Research Topic Classifications: |
| Materials Characterisation |
Tissue Engineering |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Bioactive glasses undergo degradation and dissolution in the human body. They form apatite the the bone mineral on their surface and integrate and bond well to bone. Despite their use clinically over the last twenty years their detailed mechanisms of degradation and the relationship between glass composition, glass structure and the speed at which they degrade are not understood.This proposal will address these points. It aims to understand the relationships between glass composition, glass structure, glass degradation and the physical properties of the glass such as; glass transition temperature, themal expansion coefficient, density and crystallisation behaviour.The proposal will characterise the chemical structure of the glass using solid state Nuclear Magnetic Resonance (NMR) spectroscopy. The degradation of the glass will be followed by measuring the dissolution behaviour and the type and number of ions released. The degradation behaviour will also be followed by NMR. The physical properties of the glass as well as the crystallisation behaviour will be characterised.The research will result in a detailed understanding that will enable the chemical and physical properties of bioactive glasses to be manipulated and altered, enabling bioactive glasses to be designed for specific applications for the first time.The data and know how generated will be used to design and produce new porous bioactive tissue engineered scaffolds for use in medicine.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.imperial.ac.uk |