| EPSRC Reference: |
EP/D05561X/1 |
| Title: |
Self-Organisation of Phospholipid Films on Au Electrodes Studied with In Situ Infrared Spectroscopy |
| Principal Investigator: |
Horswell, Dr SL |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Birmingham |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
15 March 2006 |
Ends: |
14 September 2009 |
Value (£): |
121,352
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| EPSRC Research Topic Classifications: |
| Chemical Structure |
Electrochemical Science & Eng. |
| Surfaces & Interfaces |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This proposal seeks to investigate the physicochemical properties of phospholipid bilayers formed at electrode surfaces, using powerful in situ infrared spectroscopic techniques. Lipid bilayers are particularly attractive models for biological cell membranes and the proposed research will provide a quantitative understanding of the structure and organisation of lipid films, which can be exploited to study binding and function of proteins and to manufacture biosensors. The strategy of this project is to progress from simple models towards more complex and physiologically realistic systems. Its essence is the combination of the control of an electric field and the simultaneous acquisition of structural information at the molecular level to probe biomimetic films. The electric field is controlled by varying the potential applied to the electrode and is of intensity comparable with those experienced by biological membranes. The following key issues will be addressed: the effect of lipid headgroup on molecular packing of the films, the influence of the applied electric field on the organisation of the films and the structural effect of protein binding on the membrane.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bham.ac.uk |