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EPSRC Reference:
EP/D07410X/1
Title:
Enzyme Responsive Materials for Biology and Medicine
Principal Investigator:
Ulijn, Professor R
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:
Materials
Organisation:
University of Manchester, The
Scheme:
Advanced Fellowship
Starts:
01 August 2006
Ends:
31 August 2008
Value (£):
649,958
EPSRC Research Topic Classifications:
Chemical Structure
Complex fluids & soft solids
Drug Formulation & Delivery
EPSRC Industrial Sector Classifications:
Healthcare
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Panel Date
Panel Name
Outcome
20 Apr 2006
Materials Fellowships 2006 - Interview Panel
Deferred
31 Mar 2006
Materials Fellowships 2006 - Sift Panel
Deferred
Summary on Grant Application Form
This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.
Key Findings
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Potential use in non-academic contexts
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Impacts
Description
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Summary
Date Materialised
Sectors submitted by the Researcher
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Project URL:
Further Information:
Organisation Website:
http://www.man.ac.uk