| EPSRC Reference: |
EP/D500869/1 |
| Title: |
Development of Novel Supported Organocatalytic Aziridination Reaction Processes |
| Principal Investigator: |
Bew, Dr S |
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| Department: |
Chemistry |
| Organisation: |
University of East Anglia |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
18 October 2005 |
Ends: |
17 October 2008 |
Value (£): |
62,549
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Catalysis & Applied Catalysis |
| Chemical Synthetic Methodology |
Reactor Engineering |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Aziridines are small reactive molecules which are very useful building blocks for making a wide variety of compounds of high value, such as medicines and functional materials. Current methods for the synthesis of aziridines are not amenable to large scale preparation, as they either use uncontrollable and unpredictable reagents (carbenes or nitrenes), or use expensive and/or toxic catalysts (rhodium or lead). At UEA we have developed two aziridination methods which employ cheap, non-toxic organocatalysts for aziridinations. In this project we will collaborate with a Chemical Engineer in order to make our aziridination procedures even more environmentally friendly and scalable. The project will also push forward the boundaries of reactor design, with the ultimate aim to incorporate multiple pathways within the reactor, such that from common starting materials several high value products can be made. Furthermore, in the future in-line monitoring of the reactions will be incorporated into the reactor design, thus allowing on-the-fly optimisation of the reactions, a concept which could potentially be applicable to any reaction, and which could save Pharmaceutical and other fine chemical producers many man-years of tedious step-wise optimisation by traditional methods.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.uea.ac.uk |