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Details of Grant 

EPSRC Reference: EP/D500869/1
Title: Development of Novel Supported Organocatalytic Aziridination Reaction Processes
Principal Investigator: Bew, Dr S
Other Investigators:
Researcher Co-Investigators:
Project Partners:
University of Bath University of East Anglia University of Sheffield
Department: Chemistry
Organisation: University of East Anglia
Scheme: Standard Research (Pre-FEC)
Starts: 18 October 2005 Ends: 17 October 2008 Value (£): 62,549
EPSRC Research Topic Classifications:
Analytical Science Catalysis & Applied Catalysis
Chemical Synthetic Methodology Reactor Engineering
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
EP/D500893/1 EP/D500885/1 EP/D500877/1
Panel History:  
Summary on Grant Application Form
Aziridines are small reactive molecules which are very useful building blocks for making a wide variety of compounds of high value, such as medicines and functional materials. Current methods for the synthesis of aziridines are not amenable to large scale preparation, as they either use uncontrollable and unpredictable reagents (carbenes or nitrenes), or use expensive and/or toxic catalysts (rhodium or lead). At UEA we have developed two aziridination methods which employ cheap, non-toxic organocatalysts for aziridinations. In this project we will collaborate with a Chemical Engineer in order to make our aziridination procedures even more environmentally friendly and scalable. The project will also push forward the boundaries of reactor design, with the ultimate aim to incorporate multiple pathways within the reactor, such that from common starting materials several high value products can be made. Furthermore, in the future in-line monitoring of the reactions will be incorporated into the reactor design, thus allowing on-the-fly optimisation of the reactions, a concept which could potentially be applicable to any reaction, and which could save Pharmaceutical and other fine chemical producers many man-years of tedious step-wise optimisation by traditional methods.
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Further Information:  
Organisation Website: http://www.uea.ac.uk