| EPSRC Reference: |
EP/E00329X/1 |
| Title: |
Fundamental Processes in Electron Capture Dissociation: Peptides, Polymers and Fullerenes |
| Principal Investigator: |
Cooper, Professor HJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Biosciences |
| Organisation: |
University of Birmingham |
| Scheme: |
Standard Research |
| Starts: |
03 September 2007 |
Ends: |
02 September 2010 |
Value (£): |
278,860
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Chemical Structure |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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A molecule's structure defines its reactivity and, in the case of biomolecules, its function. It is therefore important to be able to elucidate molecular structure. Mass spectrometry is a technique which enables measurement of the mass of a molecule. Structural information may be gleaned by fragmenting the molecule and measuring the masses of its constituent parts. Dissociation of a molecule followed by mass measurement of the fragments is known as tandem mass spectrometry. Several established techniques exist for inducing fragmentation however each has limitations, such as the inability to cleave certain chemical bonds.Electron capture dissociation (ECD) is a recently developed tandem mass spectrometry technique which shows a number of advantages for the structural analysis of peptides and proteins. However, the mechanism by which ECD occurs is not clearly defined and we cannot be certain that we are realising the potential of this analytical technique. Furthermore, the ECD of other molecular structures has not been comprehensively addressed.The proposed work will address ECD as an analytical technique in a broader context than previous investigations. We will define the ECD behaviour of particular peptides, polymers and fullerenes. The main outcome will be a better understanding of the mechanisms of ECD. As a result, it will be possible to optimise ECD performance and gain maximum structural information for a variety of molecular structures.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bham.ac.uk |