| EPSRC Reference: |
EP/E015549/1 |
| Title: |
HIGH FREQUENCY ACOUSTIC CHARACTERIZATION OF AGE-RELATED CHANGES IN MECHANICAL PROPERTIES OF TISSUE |
| Principal Investigator: |
Derby, Professor B |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
University of Manchester, The |
| Scheme: |
Standard Research |
| Starts: |
01 January 2007 |
Ends: |
30 June 2008 |
Value (£): |
164,702
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| EPSRC Research Topic Classifications: |
| Acoustics |
Development (Biosciences) |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Elastic fibres play a key role in normal tissue function, and age-related degenerative alterations in their biomechanical properties severely affect dynamic functions of the cardiovascular system, lungs and skin. This study aims to provide important information on the effects of ageing on the properties of tissue by bridging the gap between known mechanical changes at the whole tissue and molecular levels. This will be achieved through developing acoustic methods for characterising the mechanical properties of soft tissue. By using high frequency acoustic microscopy in the frequency range of 100 MHz - 1 GHz we will obtain spatially resolved maps of mechanical properties in thin histological sections with a spatial resolution in the x y plane of around 1 micron. This information will then be correlated with changes in the properties of elastic fibres extracted from tissue and combined with conventional biochemical, ultrastructural and proteomic approaches, to shed light on the causative mechanisms of elastic fibre ageing.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.man.ac.uk |