| EPSRC Reference: |
EP/E020607/1 |
| Title: |
Direct methods for the preparation of heterocycles and bis-heteroaromatics |
| Principal Investigator: |
Tomkinson, Professor NCO |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research |
| Starts: |
01 May 2007 |
Ends: |
30 April 2010 |
Value (£): |
226,481
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
Combinatorial Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Within this project we will develop new reagent based methodology to provide simple, robust and highly practical synthetic methods of broad applicability within organic synthesis. N-Methyl-O-tosyl hydroxylamine will provide a new method for the direct conversion of both aldehydes and ketones to alpha-oxysulfonyl carbonyl compounds, which, when treated directly with a variety of bis-hetero nucleophiles in-situ will provide a one-pot reaction sequence to access a variety of biologically significant heterocycles. Buchwald coupling of N-methyl-O-benzoyl hydroxylamine (and analogues) with aryl halides will lead to a cascade reaction sequence to provide direct access to bis-functionalised heteroaromatics which are present in a wide variety of both synthetic and naturally occurring compounds of biological importance. Application of these new methods to the praparation of targeted chemical arrays will provide access to a series of densely functionalised products for biological assay.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |