| EPSRC Reference: |
EP/E062091/1 |
| Title: |
Self-organization in Immune Response |
| Principal Investigator: |
Grimble, Professor MJ |
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| Department: |
Electronic and Electrical Engineering |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research |
| Starts: |
01 August 2007 |
Ends: |
31 October 2008 |
Value (£): |
106,290
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| EPSRC Research Topic Classifications: |
| Control Engineering |
Medical science & disease |
| Theoretical biology |
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The in vivo visualization of dynamic processes in lymphoid tissues by two-photon microscopy opens up possibilities for a combination of modelling, testing and experimental approaches to understand the behaviour of the immune system. A key element to develop larger models of immune response is the understanding of the cell activation, proliferation and interaction mechanisms.The aim of the project is to develop a theoretical and algorithmic framework to model and simulate the behaviour of T-cells in different environments and conditions using multi/agent dynamic systems and self-organizing systems. The proposed framework will reduce the burden on the modeling and simulation of immune system. A major step forward will be achieved by drawing inspiration from behavioural science, control engineering, physical and mathematical modelling. The final multi-agent model represents a multi-discipline integration of research concepts and simultaneously a substantial improvement of the present state of the art that fails to identify the mechanisms responsible for T-cell activation and proliferation. The integration of the activities in three research units at Strathclyde guarantees the accuracy of the final model that will be tested against a variety of experimental data and put the applicants in a unique position for the achievement of the objectives not just in the UK but also at an international level.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |