| EPSRC Reference: |
EP/E501184/1 |
| Title: |
Follow On: Novel Libraries of Building Blocks for Combinatorial Drug Discovery |
| Principal Investigator: |
Shipman, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Warwick |
| Scheme: |
Follow on Fund |
| Starts: |
27 September 2006 |
Ends: |
26 July 2007 |
Value (£): |
64,021
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
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| Panel History: |
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Summary on Grant Application Form |
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Hydantoins and their derivatives have many pharmaceutical and agrochemical applications. We have invented a simple, one-step method to an important subclass of these compounds, namely 5,5-disubstituted hydantoins. Chemical libraries of this type are rather inaccessible and appear underrepresented in commercial compound collections. Hence, there is scope to produce and market them to these industries. To develop this business opportunity, we must first establish if highthroughput techniques can be applied so that many saleable compounds can be made quickly and cheaply. Herein, we will explore both parallel synthesis methods and microwave acceleration. This project will also investigate the conversion of hydantoins into other important building blocks such as a,a-disubstituted a-amino acids. We aim to establish a company to exploit this technology and the work funded herein will produce the vital results needed to secure seedcorn funding and establish a sustainable business.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.warwick.ac.uk |