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Details of Grant 

EPSRC Reference: EP/F069103/1
Title: Stereospecific arylation of organolithiums: synthetic, mechanistic and structural investigation
Principal Investigator: Clayden, Professor J
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Manchester, The
Scheme: Standard Research
Starts: 05 January 2009 Ends: 30 June 2012 Value (£): 307,704
EPSRC Research Topic Classifications:
Asymmetric Chemistry Biological & Medicinal Chem.
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
EP/G000816/1
Panel History:
Panel DatePanel NameOutcome
06 May 2008 Chemistry Prioritisation Panel (Science) Announced
Summary on Grant Application Form
The discovery of new small molecules for use as drugs, agrochemicals, fragrances etc. relies on the availability of simple precursors that can be incorporated into more complex target molecules. The research we propose will lead to a simple and efficient way of making some classes of molecule currently considered difficult or even impossible to obtain, a limitation which means that some groups of potential targets are currently unavailable. It seeks to develop a transformation in which an aromatic ring becomes bonded to a lithium-bearing carbon atom in such a way that the shape of the starting material is remembered in the product. The products have the common feature of a highly hindered carbon atom carrying an O, N or S substituent - a feature difficult to construct by existing methods. The proposed reactions proceed by a remarkable mechanism, and by joint investigation involving both synthetic organic and structural inorganic chemists we propose to understand why the reaction works the way it does and to use this understanding to develop further related transformations.
Key Findings
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Summary
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Organisation Website: http://www.man.ac.uk