| EPSRC Reference: |
EP/G006202/1 |
| Title: |
Injectable Biomimetic Tissue Repair Systems |
| Principal Investigator: |
Tighe, Professor B |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Engineering and Applied Science |
| Organisation: |
Aston University |
| Scheme: |
Follow on Fund |
| Starts: |
01 October 2008 |
Ends: |
30 September 2009 |
Value (£): |
191,035
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Tissue Engineering |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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01 May 2008
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Follow on Fund Panel 2008
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Announced
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Summary on Grant Application Form |
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This project stems from an interdisciplinary EPSRC-funded research grant (New Clinical Materials for Biomimetic Repair of Invertebral Disc - GR/S41173/01) involving a UK-based collaborative research team comprising three complementary academic research groups and two clinical centres. The consortium brought together established expertise in synthetic polymer-based biomaterials science (Prof Brian Tighe, Aston), the biochemical and biological properties of the intervertebral disc (Dr Sally Roberts, Keele/Oswestry) and the physico-chemical characterisation of cartilaginous tissues (Dr Jill Urban, Oxford), closely linked with relevant surgical expertise in Oswestry (Dr SM Eisentstein) and Oxford (Mr. JCT Fairbank) to guide the project towards provision of an effective clinical therapy. The focussed objective of this work was the development of an injectable biomimetic hydrogel nucleus prosthesis to restore disc height in the intervertebral disc thereby avoiding the necessity for invasive surgery. We have developed such a system and brought it to the stage of pre-clinical evaluation. The three centres worked closely and successfully together and the outcome of the work may be judged from the attached final report. Further work is now necessary to facilitate the transition from the interdisciplinary science and successful outcome of the initial project to the development of a commercial product which will fill a clear clinical need, acceptable to spinal surgeons and patients.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.aston.ac.uk |