| EPSRC Reference: |
EP/G037841/1 |
| Title: |
Deconvolving of Dynamic Cell Cycle Parameters from Flow Cytometry Data |
| Principal Investigator: |
Errington, Professor RJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Medicine |
| Organisation: |
Cardiff University |
| Scheme: |
Postdoctoral Mobility |
| Starts: |
01 June 2009 |
Ends: |
31 May 2010 |
Value (£): |
118,280
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| EPSRC Research Topic Classifications: |
| Cell cycle |
Tools for the biosciences |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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10 Feb 2009
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Healthcare Engineering Panel (Eng)
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Announced
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Summary on Grant Application Form |
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Cell cycle control systems change the way in which cells behave by: checking for the completion of vital tasks, choosing different routes through the cell cycle, determining how daughter cells inherit features, fixing the lifespan of a cell, or allowing a cell to react to its neighbours and the micro-environment. For a mathematical model of the cell cycle to hold credibility and usefulness within the science community, it has be of sufficient complexity to incorporate a minimum number of processes known to be involved in cell-cycle regulation, including growth and division, growth restriction, survival, programmed cell death, DNA checkpoint control and cellular damage response. Mathematical models capable of predicting such behaviour could contribute massively to research, reducing cost and time, reducing animal experimentation, and supporting clinical trials. We understand the wider scale of this endeavour and the need for biologists and theoreticians to work closely together to deliver both a specific and ambitious objective. This PDRA mobility award provides a discipline hopping opportunity to place a young talented engineer/physicist into a 'biology' laboratory where he can understand the extent and limitations of obtaining readouts from cells and thus how to apply advanced numerical solutions for interpreting these data, while at the same time ensuring the biologist has the means for independent validation and experimental testing.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
http://www.systemscytometry.org/ |
| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |