| EPSRC Reference: |
EP/H000682/1 |
| Title: |
The use of enhanced neural response imaging to get better cochlear implant fitting for children and adults |
| Principal Investigator: |
Morse, Dr RP |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Life and Health Sciences |
| Organisation: |
Aston University |
| Scheme: |
Standard Research |
| Starts: |
01 September 2009 |
Ends: |
28 February 2013 |
Value (£): |
386,588
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| EPSRC Research Topic Classifications: |
| Biomedical neuroscience |
Med.Instrument.Device& Equip. |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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04 Jun 2009
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Engineering Med, Mech and Mat Panel
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Announced
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Summary on Grant Application Form |
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People with more severe hearing loss can be helped to hear again using a cochlear implant - a surgically implanted device that electrically stimulates the cochlear nerve (the nerve of hearing). Part of the device is a set of electrodes within the cochlea (the inner ear). Good speech perception with cochlear implants depends on appropriate adjustment of device parameters, the fitting , by an audiologist. With adults, the initial fitting is usually based on perceptual measurements that require verbal feedback from the patient. When verbal feedback is not possible, the parameters are typically set relative to the minimum level required to get a measurable electrical compound action potential (ECAP) - the summed electrical response from all the nerve fibres that can be recorded by modern cochlear implants. Standard ECAP methods, however, do not lead to a good estimate of perceptual threshold because the rate of stimulation used is much lower than that used for everyday listening; fitting based on ECAPs is therefore suboptimal. Based on our previous animal studies, we are proposing a new method to measure the ECAP threshold in humans. This method involves measuring the variability of an ECAP rather than its average size and will be both more accurate and faster. We will test the approach with cochlear implants patients from Selly Oak Hospital (Birmingham) and the House Ear Institute (Los Angeles); all tests will be in collaboration with Advanced Bionics SARL who will provide the hardware required to test patients.We will combine this method with a computer model to predict the number of cochlear nerve fibres in different regions of the patient's cochlea and determine how the current from each electrode spreads throughout the cochlea. Patient-specific models are required to account for the substantial intersubject variability arising, for example, from underlying pathology, the degree of nerve survival, and electrode placement during surgery. The model will be used to guide fitting and decide, for example, which electrodes should be active. This combination of physiological and computational techniques will overcome the limitation of using ECAPs alone to determine channel interaction (how the nerve activity generated by different electrodes overlap): With the standard use of ECAPs to gauge channel interaction, the effect of fibre distribution and current spread cannot be separated. Such a distinction is clinically important because electrodes need not be made inactive for low nerve survival alone.During the project, these patient-specific models will be extended to predict the pattern of nerve activity in response to more general stimuli. The initial model will be modified so that nerve fibres are simulated by a nerve model we have previously developed. The patient-specific parameters from the model will be selected to match ECAP data, which will require the development of novel physiological methods to improve the reliability of the data. In the later stages of the project, the model will be used to relate perceptual measures to the predicted nerve activity and therefore enable a greater understanding of neural mechanisms underlying the sensory perception of electrical and acoustic stimulation. This will lead to better cochlear implant design. Contemporary fitting by an audiologist is expensive and insufficient to enable a systematic investigation of cochlear implant parameters. In future programmes of work, extended patient-specific models will be used to quickly highlight potentially useful parameter values for standard strategies, e.g. the optimum stimulation rate, and to guide the development of novel strategies. All the above ECAP methods and models will be validated with patients with whom verbal feedback is possible. The enhanced fitting procedures derived in this project are expected to increase speech intelligibility and lead to a better quality-of-life for cochlear implant users.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.aston.ac.uk |