Details of Grant

EPSRC Reference:

EP/H024654/1

Title:

In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy

Principal Investigator:

Other Investigators:

Alexander, Professor J	Graham, Professor G	Brewer, Professor J
Maffia, Dr P	McInnes, Professor I	Faulds, Professor KJ
Garside, Professor P	Mottram, Professor JC

Researcher Co-Investigators:

Project Partners:

Department:

Pure and Applied Chemistry

Organisation:

University of Strathclyde

Scheme:

Standard Research

Starts:

01 April 2010

Ends:

31 March 2011

Value (£):

201,049

EPSRC Research Topic Classifications:

Biomaterials	Cells
Drug Formulation & Delivery	Med.Instrument.Device& Equip.

EPSRC Industrial Sector Classifications:

Healthcare

Related Grants:

Panel History:

Panel Date	Panel Name	Outcome
11 Sep 2009	Cross-Disciplinary Feasibility Account	Announced

Summary on Grant Application Form

The research focus of this feasibility account is in the application of nanoscience into living systems for improvement of health. There are two themes which run through this research focussing on diagnostics and therapeutics. Our existing Platform Grant has allowed us to start looking at functionalised nanoparticles as responsive nanosensors for analysing cell receptors and enzyme activity within cells based on the change in surface enhanced Raman scattering in a number of target systems. The focus so far has been on immunologically compromised cells and, through very exciting preliminary data and discussion with interested, more clinically based parties, we propose to use this feasibility account to allow us to conduct preliminary studies transposing our research to the next level and to that of genuine in vivo experimentation and implementation of nanoscience. So far, the focus has been on diagnostic information retrieval however, here we propose to couple this with a therapeutic aspect. The mounting of biological drugs, such as therapeutic antibodies, onto nanoparticles appears to have significant effect on the efficacy of the drug when used in vitro. To test this in vivo is very challenging and largely an unknown entity. New biological drugs that have been developed are not fully characterised in terms of where they locate within a body and where they provide their most beneficial action. Despite this, FDA approval has been given and we propose to use our combination of nanoscience, spectroscopy functionalisation and immunological/clinical expertise to create a series of cross disciplinary highly adventurous in vivo experiments with a view to pump priming a much larger and consolidated programme of work.

Key Findings

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Potential use in non-academic contexts

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Impacts

Description	This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised

Sectors submitted by the Researcher

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Project URL:

Further Information:

Organisation Website:

http://www.strath.ac.uk