| EPSRC Reference: |
EP/H02915X/1 |
| Title: |
Highly efficient synthesis of DNA binding polyamides for commercial exploitation |
| Principal Investigator: |
Burley, Professor GA |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
University of Leicester |
| Scheme: |
Follow on Fund |
| Starts: |
01 June 2010 |
Ends: |
31 May 2011 |
Value (£): |
128,958
|
| EPSRC Research Topic Classifications: |
| Chemical Biology |
Chemical Structure |
| Co-ordination Chemistry |
Materials Characterisation |
| Materials Synthesis & Growth |
|
|
| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Electronics |
|
| Related Grants: |
|
| Panel History: |
| Panel Date | Panel Name | Outcome |
|
21 Oct 2009
|
Follow On Fund 7
|
Announced
|
|
|
Summary on Grant Application Form |
|
Gene transcription is a central biological process that occurs in every living cell. It involves reading the genetic information stored in the cell's DNA and converting this into RNA. The ability to artificially regulate this process is a highly sought after goal in biotechnology and medicine as it would offer a tool that could validate new drug targets, investigate new biology as well as providing new therapeutics. DNA binding polyamides are small molecules that can regulate gene transcription. They are the only class of small molecules that can target virtually any DNA sequence, yet a significant barrier to widespread adoption is the ability to manufacture diverse collections of polyamides in high yield and purity in a quick cost-effective manner. A novel method for the synthesis of DNA-binding polyamides has been developed at Leicester that enables their preparation in high yield and purity and at low cost; thus overcoming the major barrier to market entry. The Leicester method results in increases in overall yield of up to 330-fold relative to the current state of the art.The aim of this Follow-on Fund project is to automate and optimise the scalable production of polyamides and to further biological validation by end users and licensees. These pre-commercialisation activities will enhance the patented technology for commercialisation and lay the foundation for their widespread utilisation in biology and medicine.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.le.ac.uk |