Details of Grant 

EPSRC Reference:	EP/I001697/1
Title:	POLYMER NANOMEDICINE: ENHANCING THE TRANSLATION FROM THE LAB TO THE CLINIC
Principal Investigator:	Battaglia, Professor G
Other Investigators:	Armes, Professor SP Azzouz, Professor M Brown, Professor NJ
Researcher Co-Investigators:
Project Partners:	Biocompatibles Ltd
Department:	Biomedical Science
Organisation:	University of Sheffield
Scheme:	Standard Research
Starts:	01 July 2010	Ends:	30 June 2014	Value (£):	964,752
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Medical science & disease Particle Technology
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:	Panel Date Panel Name Outcome 16 Mar 2010 Healthcare Partnerships Announced
Summary on Grant Application Form
There is a necessity to speed up the process of design, optimization and evaluation of formulation for biomedical applications. Such a process is even more crucial when it comes to the engineering novel nanometer-sized particles that can deliver therapeutic agents across the different barrier targeting only the damaged sites. Today such effort collectively known as Nanomedicine, is revolutionizing traditional therapy and enabling completely new therapeutic and diagnostic approaches. Nanomedicine is a multifaceted discipline that involves physicists, chemists, engineers, biologists and clinicians. This interdisciplinary nature is possibly nanomedicine greatest strength and greatest weakness at the same time. Indeed while this allows a more complete understanding of the different physico-chemical aspects as well as the biological implications, often the methodologies and the approaches are substantially different across the different disciplines hindering the validation and the fast translation of the final results. Herein we propose a rigorous approach of synthesis and pre-clincial evaluation of many nanoparticles for the delivery of theraupetic genetic materials. These will be screened developing and employing state-of-the-art biological evaluations adapted for nanoparticles. We plan to screen for thousands of formulation and aiming to identify few that will have a tremendous impact in both cancer therapy and motoneuron-degenerative disorders.
Key Findings
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Further Information:
Organisation Website:	http://www.shef.ac.uk