| EPSRC Reference: |
EP/I006605/1 |
| Title: |
A Claisen-Sakurai Strategy to Highly Substituted Cyclopentenols: Applications to the Syntheses of Echinopine A and B |
| Principal Investigator: |
Cook, Dr MJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry and Chemical Eng |
| Organisation: |
Queen's University of Belfast |
| Scheme: |
First Grant - Revised 2009 |
| Starts: |
07 September 2010 |
Ends: |
06 September 2012 |
Value (£): |
100,847
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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07 Jul 2010
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Physical Sciences Panel - Chemistry
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Announced
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Summary on Grant Application Form |
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The development of new synthetic method is key to the evolution of organic chemistry. In particular new methods that can produce molecules with dense functionality in just a few steps is a shared goal. We are proposing combining two well know reactions (the Claisen rearrangement and Sakurai allylation) to create a new domino reaction that can produce molecules with complex functionalilty embedded within it in a single transformation. These densly functionalised small molecules could be of use in both the total synthesis of natural products and in the discovery of new pharmaceutical products. With this grant a new way of making complex molecules rapidly will be developed. We hope to apply this to the rapid synthesis of compounds that exhibit potent biological properties, both natural and unnatural. We will embark on a synthesis of echinopinine A and B two complex natural products with novel architectures. Although their biological properties have not been fully elucidated they were isolated from plants known to exhibit many medicinal properties including anti-cancer activity.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.qub.ac.uk |