| EPSRC Reference: |
EP/P016898/1 |
| Title: |
The Synthetic Biological Engineering of Self-Assembling Micro-Hearts for Cardiac Drug Testing |
| Principal Investigator: |
Balint, Dr R |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
University of Manchester, The |
| Scheme: |
EPSRC Fellowship |
| Starts: |
01 April 2017 |
Ends: |
31 August 2020 |
Value (£): |
355,703
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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Pharmaceutical drug development is increasingly more expensive and time consuming due to the lack of effective laboratory tissue/disease models that accurately predict drug efficacy and safety. In this fellowship I will address this challenge by combining synthetic biology with tissue engineering. Focusing on cardiac drug testing, I will reprogram stem cells through synthetic biology to automatically self-assemble into small, 0.5-1 mm diameter spherical heart tissue constructs (i.e. micro-hearts). Synthetic biologically engineered micro-hearts satisfy all requirements of an effective cardiac drug testing tool, and are cheaper than currently used methodologies. As an effective and inexpensive drug testing tool it will help reduce the cost of drug development, helping the pharmaceutical industry, an £8.8 billion UK sector, survive and thrive. Cheaper and more effective cardiac drugs will lessen the £11 billion burden of cardiovascular diseases on the NHS, and improve the quality of life of the 7 million people living with these diseases today in the UK.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.man.ac.uk |