| EPSRC Reference: |
EP/P025226/1 |
| Title: |
New Strategies to Nitrogen Heterocycles by Alkyne Functionalisation/6pi-Electrocyclisation |
| Principal Investigator: |
Harrity, Professor JPA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research |
| Starts: |
02 July 2017 |
Ends: |
04 December 2020 |
Value (£): |
325,040
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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24 Jan 2017
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EPSRC Physical Sciences - January 2017
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Announced
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Summary on Grant Application Form |
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Aromatic compounds play a leading role in all aspects of the chemical sciences, and are found as core molecular fragments in a wide range of areas from coordination complexes to bioactive molecules and smart materials. Their application in these areas is dependent on our ability to design and tailor-make bespoke variants that will participate in further chemical modifications towards specific and intended target compounds. We have developed a way to make these compounds in a predictable manner, that controls the incorporation of functionalisable groups at specific positions on the aromatic ring. These functionalisable groups are based on boron, a privileged group in organic chemistry that mediates a very broad range of reactions. Using our approach, we will exploit borylated starting materials by showing how they can (1) play a key role in taking the starting materials to products by reacting with an alkyne unit in the substrates; (2) by forming a handle for further chemical modifications. We are only just beginning to understand the scope of this process, but we believe that it will represent a general method for preparing these important compounds. The requested grant will allow us to demonstrate the potential of the methodology, and will show that we can use it to access a very broad range of high value chemicals.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |