| EPSRC Reference: |
EP/P02985X/1 |
| Title: |
Aluminium nitride - graphene dual-mode sensors for cancer cell detection |
| Principal Investigator: |
Klein, Professor N |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research |
| Starts: |
01 January 2018 |
Ends: |
30 June 2021 |
Value (£): |
1,158,109
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| EPSRC Research Topic Classifications: |
| Bioelectronic Devices |
Materials Characterisation |
| Med.Instrument.Device& Equip. |
Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
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Summary on Grant Application Form |
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We propose to develop a technology for wafer scale device fabrication based on thin film heterostructures composed of graphene and aluminium nitride (AlN), which were recently demonstrated by our team for the first time. As a new orthogonal approach for biosensors, AlN-graphene heterostructures should enable simultaneous mass and charge detection of immobilized cellular and molecular species within one integrated device. This new capability is expected to lead to a dramatic reduction of false positives and false negatives in cancer cell detection based on antigen-antibody bond-mediated cell capturing. : As a bioactive sensor surface, bio-functionalized graphene enables charge detection via the electric field effect in graphene. Simultaneously, the graphene biointerface layer will be employed as an electrode - in combination with other graphene layer(s) embedded inside the heterostructure - to enable a fully integrated piezoelectric excitation and readout of mechanical deformations or oscillations of a free-standing AlN structure. Cell capture-induced alterations of the deformation or mechanical resonance should allow mass detection of the immobilized species. This orthogonal sensing capability of fully integrated devices will be tested and benchmarked for detection of cancer cells in blood or other body fluids.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |