| EPSRC Reference: |
GR/H52917/01 |
| Title: |
DEVELOPMENT AND TESTING OF A PHYSIOLOGICALLY BASED COMPUTATIONAL MODEL OF THE PERIPHERAL AUDITORY SYSTEM |
| Principal Investigator: |
Evans, Professor E |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Life Sciences (closed) |
| Organisation: |
Keele University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
21 June 1993 |
Ends: |
20 February 1997 |
Value (£): |
138,038
|
| EPSRC Research Topic Classifications: |
| Vision & Senses - ICT appl. |
|
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Parallel physiological investigations and development of existing and new models to: model level-dependent properties of cochlear nerve fibres, particularly associated with their filtering and automatic gain control properties; model onset categories of cells in the cochlear nucleus, with particular reference to their ability to extract (pseudo-) fundamentals from (in)harmonic complexes; model dorsal cochlear nucleus cell types, particularly giant cells, exploiting our physiological ability to dissect out the contributions of the different inhibitory mechanisms in the cochlear nucleus, by neuropharmacological means.Progress:1. Physiological investigationsThese have concentrated on giant cells in the dorsal cochlear nucleus, using neuropharmacological dissection of the main inhibitory mechanisms. Firstly, a systematic study is nearing completion of the shifts in dynamic range produced by the addition of background noise or tones. These data show conclusively that the major component of these shifts is produced by glycinergic lateral inhibition. Secondly, a study is well underway of the mechanisms underlying off-inhibition. This phenomenon can be divided a first, early, phase, mediated by GABAa receptor mechanisms, and a second, later phase by GABAb receptors. 2. ModellingThe cochlea, and cochlear nerve components of the model have been successfully implemented in LabView. The model is currently being used to investigate the level-dependent properties at the cochlear nerve level, particularly the non-linearities associated with the automatic gain control stage. An unexpected by-product of the model is its utility for teaching: users can run the model on a PC, generating and manipulating stimuli, and observing graphically and acoustically the results, in real time.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.keele.ac.uk |