| EPSRC Reference: |
GR/H69311/01 |
| Title: |
SELF-ORGANISING SUPRAMOLECULAR TEMPLATES. |
| Principal Investigator: |
Moore, Dr BD |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 March 1993 |
Ends: |
29 February 1996 |
Value (£): |
107,636
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Summary on Grant Application Form |
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The programme will investigate whether helical peptides can be used to form self-organising supramolecular templates that will enable molecular scale electronic components to be immobilised at precisely located sites in ordered arrays. It will involve i) determination of the best amino-acid sequences and the siting of appropriate complementary side chains using computer modelling and energy minimisation program; ii) synthesis of oligopeptides using FMOC chemistry on an automated solid- phase peptide synthesiser; iii) HPLC pruification and characterisation using NMR, FAB-MS and amino-acid analysis; iv) formation of conformationally confined peptide monolayers from solution by affinity aggregation and specific adsorption of the methionine thioether side chains at clean gold surfaces; v) full characterisation of the self-assembled monolayers by surface-sensitive techniques including ellipsometry, electrochemistry, XPES surfacepenhanced resonance Raman, and infrared reflection-absorption spectroscopy; vi) imaging of individual peptide templates using scanning tunneling electron microscopy.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |