| EPSRC Reference: |
GR/K53987/02 |
| Title: |
SYNTHESIS OF MARINE ANTITUMOUR AND ANTIVIRAL AGENTS |
| Principal Investigator: |
Kocienski, Professor P |
| Other Investigators: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 1997 |
Ends: |
03 January 1999 |
Value (£): |
96,921
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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Summary on Grant Application Form |
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A preclinical investigation has revealed that the mycalamides isolated from marine sources are amongst the most potent agents active against human solid tumours discovered to date. They are also active against viruses (Herpes and Poliomyelitis). A synthesis of the mycalamides launched in 1991 will be completed and extended to the theopederins, only discovered in 1992, which show similar activity but benefit from diminished cytotoxicity. Owing to the difficulty of isolating the natural compounds from marine sources, organic synthesis will be essential to elucidating the mode of action and toxicology of these promising new agents.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |