| EPSRC Reference: |
GR/K57886/01 |
| Title: |
CHIRAL ELECTROCHROMATOGRAPHY |
| Principal Investigator: |
Bartle, Professor K |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 1996 |
Ends: |
30 June 1998 |
Value (£): |
98,572
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Food and Drink |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Computational methods now being developed (6) to determine the degree of selective binding, of enantiomers to a silica-based chiral stationary phase will be extended to the design of the active groups for use in (reverse-phase) electrochromatography. The groups will be synthesized and bonded on to small diameter (1-3m) silica particles in cooperation with Phase Separations Ltd who will provide advice (Dr P Myers), raw materials, and some of the special facilities for synthesis.The particles will then by packed (3) into fused silica capillaries with supercritical CO2 as carrier; the density of the packed bed will be controlled by varying the CO2 density. The performance of the resulting columns for the separation of a variety of racemic mixtures of pharmaceutical, crop-protection and food industry interest will be investigated first in HPLC and then electrochromatographic mode, Systemmatic investigations will be made of other factors affecting electrochromatographic performance, eg field strength; buffer concentration and pH:ionic strength; and organic modifier.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |