| EPSRC Reference: |
GR/K58869/01 |
| Title: |
A NEW METHODOLOGY FOR THE CONCISE PREPARATION OF OLIGOSACCHARIDES OF BIOLOGICAL IMPORTANCE |
| Principal Investigator: |
Boons, Professor G |
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| Department: |
School of Chemistry |
| Organisation: |
University of Birmingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
15 January 1996 |
Ends: |
14 January 1999 |
Value (£): |
142,216
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Summary on Grant Application Form |
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The aim of this research is to develop a novel latent-active glycosylation strategy. This glycosylation strategy is based on isomerisation of substituted allyl glycosides to give vinyl glycosides which can subsequently be user in Lewis acid-mediated glycosylation reactions. This approach will enable the preparation of complex oligosaccharides of biological importance in a highly convergent manner.The work will include: (i) the preparation of a range of allyl glycosides which can readily be isomerised to the corresponding vinyl glycosides and these substrates will be used to synthesise both a- and b-glycosidic linkages; (ii) the use of reactive Rh and Ni catalysts, which will isomerise more efficiently the allyl glycosides and which will allow the isomerisation and glycosylation to be performed as a one pot procedure; (iii) the preparation of allyl glycosides containing a non-chiral allyl substituent such that they can be used in the active-latent glycosylation strategy; (iv) the development of methodology to convert vinyl glycosides into other glycosyl donors; (v) the preparation of oligosaccharide fragments of natural importance using the novel latent-active glycosylation strategy.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bham.ac.uk |