| EPSRC Reference: |
GR/L58538/01 |
| Title: |
SHINING NEW LIGHT ON INDUSTRIAL RADICAL CHEMISTRY |
| Principal Investigator: |
Parsons, Professor A |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of York |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1997 |
Ends: |
30 September 2000 |
Value (£): |
40,902
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The application of an unconvetional method of carbon-carbon bond formation using a light-initiated radical process will be investigated. This approach benefits from the cheap, technically clean controllable method of radical generation and has enormous potential for large scale synthesis in the chemical industry. At present this important type of reaction is rarely (if ever) considered by the industrial chemist for carbon-carbon bond formation and there is an urgent need for the development and utilisation of radical intermediates in bulk chemical synthesis. The project will address the feasibility of this method and help to change current thinking towards the application of radicals in the preparation of a variety of industrially important amino acids. Investigations will concentrate on applying this method to alkylate glycine to afford a novel approach to a variety of racemic and chiral amino acids. These studies will explore the generality and efficiency of this method on a multigram scale. Particular attention will be drawn to the application of this methodolgy to the synthesis of three biologically active amino acids (levodopa, melphalan and levothyroxin) of considerable industrial importance.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.york.ac.uk |