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Details of Grant 

EPSRC Reference: GR/L58811/01
Title: CATALYTIC ASYMMETRIC HETEROGENEOUS HYDROGENATION
Principal Investigator: Gilmore, Professor C
Other Investigators:
Webb, Professor G Colvin, Dr E
Researcher Co-Investigators:
Project Partners:
GlaxoSmithKline plc (GSK)
Department: School of Chemistry
Organisation: University of Glasgow
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1997 Ends: 30 September 2000 Value (£): 145,710
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
A preliminary screening of certain prochiral substituted alkenes has shown that they can be hydrogenated under heterogeneous conditions, employing a cinchona-modified Pt catalyst, in exceptionally high enantiomeric stress. It is planned to investiagte the generality of this process with a range of other prochiral alkenes, all of whose hydrogenation products are pharmaceutically valuable, especially in chiral non-racemic form. Initial indications promise considerable generality. It is then planned to investigate the mechanism of this process, to allow substrate predictiability. Finally it is planned to address the practicalities of scale-up. The aim of all of these objectives is to provide lower manufacturing costs and cleaner synthetic processes in the production of industrual chemicals, in response to the recent EPSRC call for proposals on this theme.
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Organisation Website: http://www.gla.ac.uk