| EPSRC Reference: |
GR/L59375/01 |
| Title: |
ROPA:BIOMECHANICALLY INTERACTIVE STUDY OF WEAR DEBRIS INDUCED OSTEOLYSIS IN ARTIFICIAL HIP JOINTS |
| Principal Investigator: |
Fisher, Professor J |
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| Department: |
Mechanical Engineering |
| Organisation: |
University of Leeds |
| Scheme: |
ROPA |
| Starts: |
01 January 1998 |
Ends: |
31 December 1999 |
Value (£): |
102,892
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Summary on Grant Application Form |
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Osteolysis caused by micron and submicron size wear is a major cause of long term failure in artificial hip joints. Currently, over 1% of the population benefit from these implants, and run the risk of failure and revision operations. We have recently identified through static cell culture models a critical size range in which polyethlene wear partlcles are biologically active. We postulate that there is also a biomechanical strain environment that stimulates bone resorption in the presence of wear debis. A novel biomechanically dyanmic cell culture model will be developed and validated to study wear debris induced osteolysis.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |