| EPSRC Reference: |
GR/L60968/02 |
| Title: |
POLY-Y-D-GLUTAMIC ACID AS A TEMPLATE FOR FUNCTIONALISED WATER-SOLUBLE BIOMATERIALS |
| Principal Investigator: |
Bugg, Professor TDH |
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| Department: |
Chemistry |
| Organisation: |
University of Warwick |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 1999 |
Ends: |
30 September 2000 |
Value (£): |
17,496
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| EPSRC Research Topic Classifications: |
| Materials Synthesis & Growth |
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed research involves the covalent modification of the bio-polymer poly-g-D-glutamic acid by biologically active ligands using a recently established procedure. Poly-g-D-glutamic acid will be modified with a sialic acid glycoside, to yield a polyvalent sialic acid conjugate which it is hoped will bind tightly to influenza virus haemagglutinin, and hence show activity against influenza virus infection. Poly-g-D-glutamic acid will also be modified by the antibiotic vancomycin, which functions by complexation of the peptidyl-D-Ala-D-Ala termini on bacterial cell surfaces. It is hoped that the polyvalent vacomycin binding will show enhanced activity against vancomycin-resistant bacterial strains.A poly-g-D-glutamic acid depolymerase enzyme which breaks down the polymer will also be studied in connection with possible applications of functionalised polymeric materials. The enzyme will be purified using a new continuous assay, and its ability to break down modified poly-g-D-glutamic acids studied. Possible applications of multi-valent poly-g-D-glutamic acid as affinity agents for protein purification will be examined.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.warwick.ac.uk |