| EPSRC Reference: |
GR/L62856/01 |
| Title: |
A TOTAL SYNTHESIS OF NEOLIACINIC ACID |
| Principal Investigator: |
Clark, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 1997 |
Ends: |
31 December 2000 |
Value (£): |
145,111
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Neoliacinic acid is an architecturally complex plant metabolite with potential anti-cancer activity. The unusual tricyclic structure and dense functionality present in neoliacinic acid coupled with its putative biological activity, make it a highly attractive target for synthesis. In spite of this, there have been few previous studies concerning the synthesis neoliacinic acid.The aim of the proposed research is the construction of the natural product by a route that is both efficient and conceptually novel. In the proposed synthesis, the tricyclic core of neoliacinic acid will be constructed using new catalytic reactions which involve highly reactive metal carbenoid intermediates.Metal-mediated reactions will also be used for the controlled introduction of the dense array of oxygen-containing functional groups found tin the natural product. The proposed synthesis of neoliacinic acid will be distinctive in terms of the synthetic strategy and the catalytic reactions used.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |