| EPSRC Reference: |
GR/L66519/01 |
| Title: |
CHIRAL PHOSPHORUS CARBENES EXPLOITING THE FIRST CHIRAL PHOSPHENIUM SALTS IN SYNTHESIS AND ANALYSIS |
| Principal Investigator: |
Kee, Dr T |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
30 September 2001 |
Value (£): |
49,809
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Following our recently patented synthesis of the first class of chiral phosphenium salts (CPSs), the phosphorus analogues of singlet carbenes, we seek here to develop the chemistry of such species in two principal phases. Phase one involves an examination of (1) the synthetic scope and (2|) important aspects of the chemical and physical properties of CPSs whilst Phase two is a detailed investigation of how CPSs can be exploited in three strategic areas: (1) Synthesis. Asymmetric synthesis of chiral organophosphorus compounds through CPS reagents. For example, exploitation of the asymmetric phospho-Diels Alder reaction and the activation of [C-H] bonds via CPSs.(2) Analysis. The development of novel chiral derivatising agents based on CPSs for assaying enantiopurity of both electrophilic and nucleophilic compounds. (3) Catalysis. An exploration of enantioselective processes employing CPSs as innovative chiral Lewis acids, the first such examples based on a metal-free phosphorus compound. Processes include the BH3-mediated reduction of [C=X] functions (X = O, NR), aziridination and cyclopropanation3 of prochiral alkenes and addition of allyl stannes or silanes to carbonyls.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |