| EPSRC Reference: |
GR/L70387/01 |
| Title: |
SUPERHEATED WATER AS A SOLVENT-FREE ELUENT FOR LIQUID CHROMATOGRAPHY AND RELATED ANALYTICAL TECHNIQUES |
| Principal Investigator: |
Smith, Professor R |
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| Department: |
Chemistry |
| Organisation: |
Loughborough University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
16 November 1997 |
Ends: |
15 November 2000 |
Value (£): |
81,959
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The project will study the application of superheated water (between 100 and 200 c)as an alternative non-polar eluent to organic-aqueous solvent mixtures in reversed-phase HPLC and solid phase extraction. It will primarily examine the use of superheated water for liquid chromatography with microprobe or packed capillary columns, whose application in liquid chromatography has frequently been limited by sensitivity. A flame ionisation detector will be used to increase the sensitivity and to obtain universal detection in comparison to conventional HPLC spectroscopic detection. Selective detectors will also be examined. Temperature programming will be used to achieve gradient elution, which is normally difficult in capillary liquid chromatography.The study will examine the different temperatures, flow and pressure conditions on the separation selectivity and efficiency in comparison to conventional HPLC methods. The influence of acids, basic and ion-pair reagents on the separation of neutral and ionisable analytes will also be studied.The application of superheated water as an eluent for solid phase extraction will also be examined as a form of liquid phase thermal desorption and the possibility of water based coupled SFE-LC systems will be explored.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.lboro.ac.uk |