| EPSRC Reference: |
GR/L70653/01 |
| Title: |
ROPA:NOVEL ALGINATE-GROWTH FACTOR HYDROGEL FOR DENTAL TISSUE WOUND HEALING |
| Principal Investigator: |
Smith, Professor A |
| Other Investigators: |
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| Department: |
Dentistry |
| Organisation: |
University of Birmingham |
| Scheme: |
ROPA |
| Starts: |
10 November 1997 |
Ends: |
09 November 1999 |
Value (£): |
73,806
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Existing methods of treatment (calcium hydroxide) for treatment of gross dental caries involving pulpal exposure show variable success. The present proposal involves development of a novel approach to wound healing in these tissues developmental events are mimicked by presentation of Transforming Growth Factor- b1 in an alginate hydrogel to simulate the dental basement membrane, which controls dental cytodifferentiation during tooth development. The design requirements for this cellular engineering approach wound healing in the dental tissues will be addressed and the system evaluated in a human dental tissue organ culture to characterize cellular events during healing.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bham.ac.uk |