| EPSRC Reference: |
GR/L94697/01 |
| Title: |
THE TOTAL SYNTHESIS OF THE GALBONOLIDES AND THE UTILITY OF NOVEL ORGANOZINC REAGENTS |
| Principal Investigator: |
Parsons, Professor P |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Sussex |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
27 April 1998 |
Ends: |
26 April 2001 |
Value (£): |
147,646
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The primary aim of the proposed research is to develop a new synthetic approach to the important antifungal galbonolides. Our route will uncover novel methodology for the construction of a key fragment of the immunosuppressant rapamycin and other natural products containing remote chiral centres.This work was devised to develop methods for remote asymmetric control and to incorporate diene functionality, to allow further elaboration of chirality.In addition we seek to explore the novel chemistry of an organozinc mediated rearrangement which will provide an ideal postgraduate training.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.sussex.ac.uk |