| EPSRC Reference: |
GR/L96554/01 |
| Title: |
PARTICLE FORMATION IN SUPERCRITICAL FLUIDS |
| Principal Investigator: |
Shekunov, Dr B |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Pharmacy |
| Organisation: |
University of Bradford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 1998 |
Ends: |
31 August 2001 |
Value (£): |
176,671
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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Main objective: To investigate the phenomena of turbulent micromixing and particle formation in multi-component supercritical flows and, using this knowledge, to develop new applications of supercritical fluid technology in the area of pharmaceutical formulation and chemical production.Secondary Objective: To develop optical and x-ray analytical techniques to study supercritical fluids in situ.Background: Current crystallisation methods are non-ideal; control over the physical form and crystallinity of the drugs remain poor, process conditions and formulations are often empirically derived and lack efficiency.Supercritical fluids open up a novel way of crystallising materials, such that the desired particle characteristics are conferred during crystallisation.Programme: Crystallisation and mass-transfer phenomena in carbon dioxide/organic solvent/drug systems will be investigated using in situ optical and X-ray techniques in order to analyse and optimise the particle formation process. Theoretical modelling will enable the kinetics of particle formation and particle size distribution to be calculated, and the process to be scaled-up to pilot production level.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.brad.ac.uk |