| EPSRC Reference: |
GR/M05461/01 |
| Title: |
TOTAL SYNTHESIS OF THE AZINOMYCINS |
| Principal Investigator: |
Shipman, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
16 November 1998 |
Ends: |
15 January 2002 |
Value (£): |
148,004
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The azinomycins are a unique class of natural products that possess potent anti-tumor activity. Under this programme, we propose to draw on our existing expertise in this research field to complete the total synthesis of these complex and highly sensitive chemical targets. As no research group as yet accomplished this goal, the successful completion of the synthesis of azinomycin A or azinomycin B would represent a significant landmark in this internationally competitive field.In the proposal, we detail two novel approaches to the 1-azabicyclo[3.1.0]hexan ring system of the azinomycins which we believe will offer highly expedient routes to the azinomycins. Our general strategy relies on recognising that either the alpha- or beta-nitrogen atoms of the dehydroamino acid can be introduced by condensation of an amine (or amide) with the corresponding alpha-keto acid or beta-keto ester followed by subsequent imine-enamine tautomerisation. Further elaboration of the intermediates produced using this new chemistry should provide short routes to both azinomycin A and B.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |