Details of Grant 

EPSRC Reference:	GR/M06444/01
Title:	THE DEVELOPMENT AND APPLICATION OF ENANTIOTOPIC GROUP- SELECTIVE PALLADIUM INSERTIONS IN SYNTHESIS
Principal Investigator:	Willis, Professor M
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Bath
Scheme:	Standard Research (Pre-FEC)
Starts:	01 September 1998	Ends:	31 August 2001	Value (£):	53,411
EPSRC Research Topic Classifications:	Asymmetric Chemistry
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
The proposed research will develop the use of chiral palladium catalysts to achieve the desymmetrisation of symmetrical divinylhalide substrates. Both 1, 1- and 1, 2-divinylhalides will be explored, providing structurally varied products. A desymmetrissing approach such as this is expected to provide material of high enantiomeric excess as it combines an initial enantioselective operation with a kinetic resolution. The range of reactions that can be used to functionalise the chiral palladium species produced will be examined so as to provide a further element of diversity. The functionalised enatiomerically enriched products will be exploited in synthetic applications. In particular a total synthesis of the analgesic alkaloid epibatidine will be undertaken.
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Organisation Website:	http://www.bath.ac.uk