| EPSRC Reference: |
GR/M14258/02 |
| Title: |
THE DEVELOPMENT OF A NEW (5+2) PHOTOCYCLOADDITION SEQUENCE FOR THE RAPID CONSTRUCTION OF ALKALOIDS |
| Principal Investigator: |
Booker-Milburn, Professor KI |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
31 December 2000 |
Value (£): |
60,493
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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The proposed programme aims to capitalise on a recent discovery from our laboratories that functionalised maleimides undergo an interesting formal [5+2] photocycloaddition to give fused bi- and tricyclic azepines in moderate to excellent yields. Once the scope and generality of this reaction has been explored, then it will be used as the key step in the construction of a number of alkaloid skeletons. This will be achieved by attaching a variety of alkene units to maleimide via Mitsunobu coupling of the corresponding alkenols. Irradiation of the resulting functionalised imides will lead to the alkaloid skeletons directly. These products will then have all the necessary functionality present to complete the synthesis of the respective alkaloids.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |