| EPSRC Reference: |
GR/M16962/01 |
| Title: |
DISSECTING METAL ION CATALYSED PHOSPHATE HYDROLYSIS |
| Principal Investigator: |
Williams, Professor NH |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
48,874
|
| EPSRC Research Topic Classifications: |
| Physical Organic Chemistry |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
This proposal is for a detailed physical organic investigation into the role of metal ions in catalysing phosphate monoester and diester hydrolysis. Several lines of study are proposed, aimed at measuring quantitatively the effect of thio substitution at phosphorus in this context, the effect of combining further catalytic modes of action and in creating a link between mechanistically useful ions such as Co(III) and biologically interesting ions such as Zn(II). This will be achieved through kinetic analysis of defined complexes, where the contact between phosphates and metal ion are known, and where the mechanism of action can be shown. Based on the initial results, we will be able to construct more complexe models, making efficient use of any synthetic effect. The results will be applicable to understanding important biological catalysts which utilise metal ions for catalysis and to designing better artificial catalysts.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.shef.ac.uk |