| EPSRC Reference: |
GR/M23021/01 |
| Title: |
RESOLUTION METHODS FOR ASYMMETRIC SYNTHESIS |
| Principal Investigator: |
Caddick, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Sussex |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 1999 |
Ends: |
31 July 2001 |
Value (£): |
96,937
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The project will examine new resolution methods for asymmetric synthesis and will largely focus on Dynamic Kinetic Resolution (DKR) which can produce desired products in yields greater than 50%. We will examine the scope of our recently developed DKR methodology and examine applications to a diverse range of alpha-amino acid derivatives. These will include carbo- and hetero-cyclic aromatic derivatives and labelled (D/F) amino acids. We will extend the approach by using a range of nucleophiles in the DKR process. We will then delineate the scope and limitations of our new auxiliary cleavage protocol and evaluate a new peptide coupling procedure. We will also evaluate a range of new kinetic resolutions (KR) and some sequences involving both DKR and KR. We will also investigate the opportunities for catalysis by examining substitution reactions of salts derived from alfa-halo-carbonyl compounds, this work is essential for the development of catalytic DKR methodologies.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.sussex.ac.uk |