| EPSRC Reference: |
GR/M36878/01 |
| Title: |
ROPA: NUCLEOPHILIC AROMATIC SUBSTITUTION REACTIONS USING SILANE REAGENTS |
| Principal Investigator: |
Clark, Professor JH |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of York |
| Scheme: |
ROPA |
| Starts: |
01 October 1998 |
Ends: |
30 September 2000 |
Value (£): |
94,063
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We have recently shown that the Me3siCF3/KF/DMAc system is capable of reacting with activated aromatic substrates by the substitution of nitro and cyano groups with CF3. In contrast, the Me3SiCF3/Me4NF/MeCN system can act as a source of nucleophilic fluorine. In this project we will study the reactions of the Me3SiCF3/F-/ solvent systems with a range of aromatics with particular interest in their use for the preparation of valuable CF3- and F-substituted aromatics. Further studies will seek to determine the generality of the use of the promoted silanes for the preparation of substituted aromatics.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.york.ac.uk |