Details of Grant 

EPSRC Reference:	GR/M46259/01
Title:	APPLICATION OF RING CLOSING METATHESIS TO THE SYNTHESIS OF FUNCTIONALISED SPIROCYCLIC KETALS
Principal Investigator:	Harrity, Professor JPA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Sheffield
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 1999	Ends:	30 September 2002	Value (£):	57,921
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
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Panel History:
Summary on Grant Application Form
A novel tandem ring closing metathesis protocol is proposed, which can be applied to the construction of highly functionalised spirocyclic ketals. Notable aspects of this new technique are that cyclic acetals of various ring sizes, bearing a range of substitution patterns will be assembled under mild and neutral conditions. We will investigate the diastereoselectivity of the reaction process by the employment of readily available enantiomerically pure precursors and apply these findings in the synthesis of biologically active target molecules. Finally, we wish to further manipulate the product spiroacetals in a range of diastereoselective reactions to furnish stereochemically pure, functionalised synthetic intermediates.
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Organisation Website:	http://www.shef.ac.uk