| EPSRC Reference: |
GR/M46686/01 |
| Title: |
TOWARDS A PRACTICAL SYNTHESIS OF (+)-DISCODERMOLIDE |
| Principal Investigator: |
Paterson, Professor I |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
19 April 1999 |
Ends: |
18 April 2000 |
Value (£): |
48,326
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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Discodermolide, a novel polyketide metabolite from the Caribbean sponge Discodermia dissoluta, has recently been shown to be a potent anti-cancer agent which has a similar microtubule-stabilising mechanism of action to the clinical drug Taxol. Notably, it is effective against Taxol-resistant cancer cells. Therefore, discodermolide is a prime candidate for clinical development as a new chemotherapeutic agent against various human cancers, which are resistant to Taxol. Unfortunately, there is a very serious supply problem hampering its development in the clinic. The current cost of isolating natural discodermolide is around $50,000 per milligram. This programme plans to develop a practical synthetic route to (+) -discodermolide, which might alleviate this supply problem. The proposed route addresses the efficient control of stereochemistry by exploiting robust aldol methodology from our laboratory.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |