| EPSRC Reference: |
GR/M50867/01 |
| Title: |
QUINUCLIDINE N-OXIDES : POWERFUL NEW METAL BINDING AGENTS FOR SYNTHETIC CHEMISTRY |
| Principal Investigator: |
ONeil, Dr IA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Liverpool |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
48,097
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Preliminary work in our laboratory has shown that quinuclidine N-Oxides (QNO) can replace the carcinogenic HMPA in several key reactions. Ames tests have shown that QNA is non mutagenic. This proposal outlines how we wish to develop our initial findings by studying the use of QNO as an HMPA replacement in further key transformations. We will also undertake the synthesis of novel QNO's which bear additional metal binding sites and study their ability to replace HMPA. Finally we wish to prepare chiral QNOs and examine their use as catalysts in the preparation of chiral B-chlorlo alcohols.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.liv.ac.uk |