| EPSRC Reference: |
GR/M59020/01 |
| Title: |
BORON DETERMINATION IN BORON NEUTRON CAPTURE THERAPY |
| Principal Investigator: |
Allen, Professor GC |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Interface Analysis Centre |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
218,218
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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Boron Neutron Capture Therapy (BNCT) is a new form of targeted radiotherapy which uses low energy thermalised neutrons to activate a boron-containing compound delivered to the tumour. In the resulting nuclear reactions, alpha particles are produced, which destroy the tumour cells in which they are initiated.This collaborative proposal, between the Interface Analysis Centre at the University of Bristol, the University of Birmingham, and the University of Oxford, aims to use a recently constructed surface analytical SIMS instrument to investigate the distribution of boron and other elements in tissue which has been treated with boron neutron capture therapy (BNCT) compounds.The results will be used to determine the effectiveness of the various boron carriers, their specificity to the tumour areas, their transport to various areas of the body, and the effectiveness of boron delivery to the cell walls, and within the cells.Attention will be given to sample preparation methods such as cryomicrotoming and gold coating, or pressing into indium and coating with indium, so as to minimise sample charging and sample damage, and allowing meaningful SIMS results to be obtained.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |